A.341 Bosentan and diclofenac prevent pulmonary hypertension in porcine endotoxin shock
نویسندگان
چکیده
منابع مشابه
Endothelin(A)-receptor antagonism attenuates pulmonary hypertension in porcine endotoxin shock.
Porcine endotoxin shock is characterized by pulmonary hypertension, decreased mean arterial pressure and deteriorated cardiac performance. These pathophysiological findings are accompanied by increased plasma endothelin-1 levels. Previous studies have shown that both the pulmonary and systemic circulation are improved by combined endothelinA- and endothelinB-receptor antagonism. This study was ...
متن کاملBosentan and improved pulmonary endothelial function in pulmonary arterial hypertension.
Development (CNPq; Brasilia, Brazil; #474621/2004-9), Rio de Janeiro Research Foundation (FAPERJ; Rio de Janeiro, Brazil; #E-26/100.461/2007), and, in part, by the Zerbini Foundation (São Paulo, Brazil). L.M. Ueno was supported by FAPESP as a post-doctoral fellow (#03/10881-2); and C.E. Negrao, M.U.P.B. Rondon and A.C.L. Nobrega were supported by CNPq (#302146/2007-5, #303518/2008-1 and #301168...
متن کاملThe endothelin receptor antagonist bosentan restores gut oxygen delivery and reverses intestinal mucosal acidosis in porcine endotoxin shock.
BACKGROUND Endothelin-1, the most potent vasoconstrictor known, is produced in septic states and may be involved in the pathophysiology of the deteriorated splanchnic circulation seen in septic shock. AIMS To elucidate the capability of bosentan, a non-peptide mixed endothelin receptor antagonist, to attenuate splanchnic blood flow disturbances and counteract intestinal mucosal acidosis in en...
متن کاملBosentan therapy for pulmonary arterial hypertension.
BACKGROUND Endothelin-1 is a potent vasoconstrictor and smooth-muscle mitogen. In a preliminary study, the orally administered dual endothelin-receptor antagonist bosentan improved exercise capacity and cardiopulmonary hemodynamics in patients with pulmonary arterial hypertension. The present trial investigated the effect of bosentan on exercise capacity in a larger number of patients and compa...
متن کاملBosentan for pulmonary hypertension secondary to idiopathic pulmonary fibrosis
Pulmonary hypertension is a poor prognostic factor in patients with interstitial lung disease. No established treatment exists for pulmonary hypertension secondary to interstitial pneumonia. We describe the case of an 81-year-old woman with idiopathic pulmonary fibrosis (IPF), who was admitted to our hospital due to aggravation of dyspnea and decreased oxygen saturation, as well as onset of ort...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1996
ISSN: 0007-0912
DOI: 10.1016/s0007-0912(18)31196-6